This invention decreases the wrinkle of the face and/or it regards the cosmetics or skin which the medicine composition includes the enkehuarin origin peptide in order to remove. The wrinkle of the face, the expression wrinkle of the face is decreased desirably and/or it removes, the skin, the aforementioned cosmetics in order to prescribe to the skin of the face desirably or the medicine composition for the skin include the peptide general formula (i) of the quantity which possesses the effect the cosmetics or skin as a medicine. In addition as for this invention, the wrinkle of the face is decreased and/or it regards the use of the peptide general formula (i) in the cosmetics or skin which manufacturing the medicine composition is removed. < Conversion I >本発明は、顔の皺を減らすおよび/または取り除くためのエンケファリン由来ペプチドを含む化粧品または皮膚用薬剤組成物に関する。顔の皺、好ましくは顔の表情皺を減らすおよび/または取り除く、皮膚、好ましくは顔の皮膚に投与するための前記化粧品または皮膚用薬剤組成物は化粧品または皮膚用薬剤として効果を有する量の一般式(I)のペプチドを含む。本発明はまた、顔の皺を減らすおよび/または取り除く化粧品または皮膚用薬剤組成物の調製における一般式(I)のペプチドの使用に関する。【化I】
