ALMA MATER STUDIORUM UNIVERSITA DI BOLOGNA;NOUSCOM AG
发明人:
ALFREDO NICOSIA,MARIA GABRIELLA CAMPADELLI
申请号：
US16307708
公开号：
US20190300862A1
申请日:
2017.06.08
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention is directed to a recombinant herpesvirus which comprises the GCN4 yeast transcription factor or a part thereof fused to or inserted into glycoprotein H and is capable of binding to a target molecule present on a cell for propagation and production of the herpesvirus. The herpesvirus may comprise additional modification in glycoprotein D and/or glycoprotein B for retargeting the herpesvirus to a diseased cell. The present invention is further directed to a nucleic acid and a vector coding for the gH, a polypeptide comprising the gH, and a cell comprising the herpesvirus, nucleic acid, vector or polypeptide. Moreover, the present invention is directed to a cell having accessible on the surface a target molecule for the GCN4 yeast transcription factor or part thereof and to a method for producing the herpesvirus in said cell.
