difficiledifficiledifficiledifficileThis disclosure relates to methods for eliciting an immune response against C. toxin A and toxin B in an adult human subject. The subject may be at risk for a primary symptomatic C. infection. In some embodiments a method is for eliciting an immune response against C. toxin A and toxin B in an adult human subject at risk for a primary symptomatic C. infection and comprises administering to the subject a composition comprising C. difficile toxoid A and toxoid B at least three times each administration being about seven days apart.