SHEIL, MEREDITH,GIFFARD, ALLAN,OLSSON, CHARLES ROBERT
申请号：
ES06721260
公开号：
ES2379190T3
申请日:
2006.03.15
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A topical analgesic composition for use on a significant open wound, said composition comprising: a first local anesthetic agent that has a rapid onset of action and present in an amount effective to anesthetize the significant open wound； a second local anesthetic that has a long duration of action and present in an amount effective to anesthetize the significant open wound； a vasoconstrictor present in an amount effective to reduce significant open wound hemorrhage and to decrease the percentage of vascular absorption of the first and second local anesthetic agent to reduce the risk of systemic toxicity； an antiseptic agent in an amount effective to minimize infection of the significant open wound； and a vehicle comprising a polyhydroxylated alcohol in combination with a cellulosic preparation that: adheres to the significant open wound； It forms a durable sticky viscous gel barrier over the significant open wound that is able to remain firmly adhered to the significant open wound until the significant open wound has closed naturally or the pain due to the significant open wound has been alleviated if not by means of a natural healing procedure； promotes and prolongs the contact of the first and second anesthetic agent and the vasoconstrictor with the significant open wound； and helps heal the significant open wound by minimizing or preventing water loss from the significant open wound and acting as a barrier against microbial contamination. wherein the composition provides an analgesic effect beyond that attributable to the first and second anesthetic agent alone while the barrier covers the significant open woundUna composición analgésica tópica para uso sobre una herida abierta significativa, comprendiendo dicha composición: un primer agente anestésico local que tiene un rápido inicio de acción y presente en una cantidad efectiva para anestesiar la herida abierta significativa； un segundo anestésico local que tiene una larga duración de acción y presente en una
