Marc Hubert Mercken,Marianne Borgers,Marc Maria Pierre Pelagie Vandermeeren,Bianca Julia J Van Broeck
申请号：
US14233068
公开号：
US08911731B2
申请日:
2012.07.06
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention provides monoclonal antibodies which specifically recognize the shorter Aβ peptides obtained after cleavage of the APP protein mediated by γ-secretase, i.e. the Aβ-peptide fragments Aβ1-37, Aβ3-37, Aβ3p-37, Aβ1-37 and Aβ11p-37, and other like fragments ending at the 37th amino acid of APP, hereinafter also referred to as the Aβx-37 peptides. It further provides hybridoma cells producing the monoclonal antibodies as well as methods for producing the antibodies and the hybridoma cells and an immunoassay for an Aβx-37 peptide by a competitive method or a sandwich method using the antibody of the present invention and methods for measuring the level of Aβx-37 peptides in a sample, such as a biological sample.
