A self-sampling device (1) for vaginal fluid from a vagina of a user, said self-sampling device (1) comprising an elongate first body (2) for insertion into the vagina of the user, and a sample collection body (3) for collecting a vaginal fluid sample from the user. The sample collection body (3) is attachable to an inner end portion (4) of the elongate first body (2) by a releasable connection means (5) comprising a shaft, a hole or recess for receiving the shaft, and a snap-locking means. The self-sampling device is used to take a vaginal fluid sample intended for subsequent laboratory analysis, for example, but not limited to, DNA analysis for HPV.