FORMULE PHARMACEUTIQUE CONTENANT D'UN DÉRIVÉ DE L'INSULINE

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专利权人:

Novo Nordisk A/S

发明人:

申请号：

EP08774077.5

公开号：

EP2167032B1

申请日:

2008.06.12

申请国别(地区):

EP

年份:

2019

代理人:

摘要：

The invention concerns a soluble pharmaceutical formulation comprising an insulin derivative wherein the formulation further comprises more than 4 zinc atoms per 6 molecules of the insulin derivative, and a citric acid monohydrate and/or a histidine compound used in an amount sufficient to increase the tendency of the insulin derivative to self-associate into dodecamers. The invention further comprises a process for preparing the soluble pharmaceutical formulation.

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