CLARIDGE, Stephen William,ISAKOVIC, Ljubomir,MANNION, Michael,RAEPPEL, Stéphane,SAAVEDRA, Oscar Mario,GAUDETTE, Frédéric,ZHAN, Lijie,ZHOU, Nancy Z.,RAEPPEL, Franck,DEZIEL, Robert,VAISBURG, Arkadii,UNO
申请号：
ES08800252
公开号：
ES2635131T3
申请日:
2008.08.28
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula (I) ** (See formula) **: and pharmaceutically acceptable salts thereof, and racemic and chimemic mixtures, diastereomers and enantiomers thereof, wherein D is selected from the group consisting of: (1 ) a 6-membered heteroaromatic ring system, furanyl, tetrahydropyridyl, thienyl, or pyrazolyl, each of which is substituted with 1 or 2 independently selected R38 groups, in which each R38 is independently selected from the group consisting of halo, - C (O) NR36R39, -C (O) O- (CH2) nNR36R39, - (CH 2) jNR39 (CH2) iS (O) j (C1-C6 alkyl), - (CH2) jNR39 (CH2) R36, -C (O) (CH2) jNR39 (CH2) nR36, - (CH2) nP (>； = O) (C1-C6 alkyl) 2, - (CH2) jNR39CH2 (CH2) nP (>； = O) (C1-alkyl C6) 2, NR13C (X1) NR13-arylP (>； = O) (C1-C6 alkyl) 2, NR13C (X1) NR13-heteroarylP (>； = O) (C1-C6 alkyl) 2, - (CH2) jNR39 ( CH2) i [O (CH2) i] x (CH2) jR99, - (CH2) jNR39 (CH2) iSO (0-2) (CH2) i [O (CH2) i] j (CH2) j R99, and - (CH2) jNR39 (CH2) jR100, in which each j is an integer that varies independently Mind from 0 to 4, n is an integer that varies from 0 to 6, x is an integer that varies from 1-6, each of i is an integer that varies independently from 1 to 3, and the remains - (CH2) i- and - (CH2) n- of the above R38 groups optionally include a double or triple carbon-carbon bond where n is an integer between 2 and 6； R36 is selected from the group consisting of H, -OH, C1-C6 alkyl, C3-C10 cycloalkyl, - (CH2) n (C6-C10 aryl), - (CH2) n (5-10 membered heterocyclyl) and - (CH2) nA4R37, in which each n is a number that varies independently from 0 to 6, A4 is selected from the group consisting of O, S, SO, and SO2； and (2) imidazolyl substituted with C1-C6 alkyl and - (CH2) jNR39 (CH2) nR36, wherein j is an integer from 0 to 4, n is an integer from 0 to 6, and R36 is - ( CH2) n3OR37 in which n3 is an integer ranging from 0 to 6, in which R37 is C1-C6 alkyl, and R39 is H； M is ** (See formula) ** Z is -O-；Un compuesto de Fórmula (I) **(Ver fórmula)** : y sales farmacéutica
