GEOFFREY ROBERT OWEN,AMY C. BROOKS,LINA F. BERNAL-PEREZ,DAVID W. STROMAN,JOSEPH J. DAJCS
申请号：
BRPI0907511
公开号：
BRPI0907511A2
申请日:
2009.02.16
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating ophthalmic bacterial infections. The present invention more particularly relates to the discovery that a 2-methyl substitution on a diazabicyclo group attached to a fluoroquinolone ring system produces improved permeability characteristics, and that a 5-amino substitution on a fluoroquinolone ring system results in improved anti-microbial activity.
