JOHNSON, MICHAEL R.,MOLINO, BRUCE F.,ZHANG, JIANZHONG,SARGENT, BRUCE J.
申请号：
ES04781545
公开号：
ES2432529T3
申请日:
2004.08.18
申请国别(地区):
ES
年份:
2013
代理人:
摘要：
A compound represented by the formula (1): * * * * formula in which X is Hydrogen, halogen, alkyl of C1 - C7, trifluoromethyl phenyl, substituted or non substituted with halogens, alquhtio C1 - C7 (phenyl alkyl, - C, - C7) - Uncle, alkyl Sulfonyl - C7, C - (alkyl or phenyl Sulfonyl - C - C7) and Hydrogen, Hi Droxilo, mercapto, a1coxi C1 - C7, Alquiltio CREL, halogen, alkyl of C1 - C7Not osustituido Frenho replaced with halogens, or - N (R R is Hydrogen or alkyl C7 c, each R is independently _ R7, - M - 0R8 (Ch), - (CH2) M - nr7rlo, - (CH), (chor8) (chor8kch, or - (CH, CH, or M - (R8), - ch, CH, or m) - ch, CH, nr7r 10 - (CH, KC (> = 0) nr7r 10 - (CH) - ZG - R7, - M - (Ch) nr 10 _ CH, (chor8) (Chor 0R8), - ch, - (CH), co, R7, R3 and R4 are each, independently, hydrogenA group represented by the formula (c), alkyl Hydroxy alkyl, - C, C7, C7, phenyl, phenyl - (alkyl C7 (c), halogenofenil) - (alkyl C7 (C, c), alquilfenilalquilo) (alcoxifenilc, C7, C7 (-, -) Rent C - naphthyl) - (alkyl C7, C7, or C - pyridyl) - (alkyl C7 (C,), under the condition that at least one of R3 and R is a group represented by the formula (a): in which rl is independently _ R7, - (CH)- 0R8 - 0 -, M - 0R8 (Ch ), _ (CH) - nr7r or _ _ (0, M _ nr7r ch) or - (CH,. ,(CHOR8)(CHOR8),-CH,OR8, -0-(CH)m(CHOR8)(CHOR8),-CH,OR8, -(CH,CH,O)m-R8, -O-(CH,CH,O)m-R ,_( CH,CH,O )m-CH,CH,N R 7 R 0, -0-( CH,CH,O )m-C H,CH,N R 7 R 10, -( C H,),-C( >=0 )NR 7 R 10, -0-( CH)m-C( >=0 )NR 7 R 10, _(CH,),-(Z)g_R7, -0-(CH)m-(Z)g-R7, -(CH,),-NR ,o-CH,~CHOR8)(CHOR8),-CH,OR8, -O-(C (H) M - (CH _ NR 10, chor8) (chor8), - ch, 0R8,- (CH), co, R7, - O - (CH) - CO M, r, os03h -, - or - - - glucuronide, or Glucose.Un compuesto representado por la fórmula (1):**Fórmula** en la que X es hidrógeno, halógeno, trifluorometilo, alquilo C1-C7 , fenilo no sustituido o sustituido con halógenos, alquHtio C1-C7, fenil-(alquil C,-C7)-tio, alquil-sulfonilo C,-C7, o fenil-(alquil C,-C7)-sulfonilo y es hidrógeno, hidroxilo, mercapto, a1coxi C1-C7
