Carlijin V. C. Bouten,Anita Mol,Marcel C. M. Rutten,Simon P. Hoerstrup,Frank P. T. Baaijens
申请号：
US11816271
公开号：
US08399243B2
申请日:
2006.02.01
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Developing heart valves are exposed to dynamic strains by applying a dynamic pressure difference over the leaflets. The flow is kept to a minimum, serving only as a perfusion system, supplying the developing tissue with fresh nutrients. Standard heart valves were engineered based on B trileaflet scaffolds seeded with cells isolated from the human saphenous vein. Tissue compaction is constrained by the stent, inducing increasing pre-strain in the tissue. The dynamic strains the tissues are exposed to via the dynamic pressure difference, are estimated using finite element methods based on the mechanical properties of the neo-tissue, in order to get inside into the strain distribution over the leaflet.
