Image processing techniques may include a methodology for normalizing medical image and/or voxel data captured under different acquisition protocols and a methodology for suppressing selected anatomical structures from medical image and/or voxel data, which may result in improved detection and/or improved rendering of other anatomical structures. The technology presented here may be used, e.g., for improved nodule detection within computed tomography (CT) scans. While presented here in the context of nodules within the lungs, these techniques may be applicable in other contexts with little modification, for example, the detection of masses and/or microcalcifications in full field mammography or breast tomosynthesis based on the suppression of glandular structures, parenchymal and vascular structures in the breast.
