The present invention primarily relates to the use of herbicide combinations comprising at least three specific herbicides or of a composition comprising such herbicide combinations for controlling harmful plants in tuberous root crop plants preferably in cassava. The present invention also relates to the use of said specific herbicide combinations or of a composition comprising said specific herbicide combinations as plant growth regulators for tuberous root crop plants preferably as plant growth regulators for cassava. Furthermore the present invention relates to a corresponding method of controlling harmful plants in tuberous root crop plants and to a corresponding method of regulating plant growth of tuberous root crop plants.