Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor, and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. The vascular access device can comprise a plurality of analyte sensors (240), a catheter (212) having a lumen (212a) and a small orifice (212b), and a connector or hub (218) including a duct (218b) and an orifice (218c) which is configured for connection with other intravenous equipment via one or more flanges (218a).
