Andrew Lawrence Feldhaus,Leon Garcia-Martinez,Benjamin H. Dutzar,Daniel S. Allison,Katie Olson Anderson,Ethan Wayne Ojala,Pei Fan,Charlie Karasek,Jenny Mulligan,Michelle Scalley-Kim,Erica Stewart,Jeff
申请号：
US14627458
公开号：
US09688754B2
申请日:
2015.02.20
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Another embodiment of this invention relates to the antibodies binding fragments thereof described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-ACTH antibodies and binding fragments thereof for the diagnosis, assessment, prevention and treatment of diseases and disorders associated with ACTH, such as Cushings Disease, Cushings Syndrome, Parkinsons disease, obesity, diabetes, sleep disorders depression, anxiety disorders, cancer, muscle atrophy, hypertension, hyperinsulinemia, cognitive dysfunction, Alzheimers disease, galactorrhea, stress related conditions, cardiac conditions, metabolic syndrome, hyperaldosteronism, Conns syndrome and familial hyperaldosteronism.
