Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人:
Rudolf Grosschedl,Henrik Flach,Sola Kim,Marlena Duchniewicz,Bernadette Schreiner,Marc Rosenbaum
申请号：
US15689948
公开号：
US20180057573A1
申请日:
2017.08.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The marginal zone (MZ) and B1 subsets of B cells, which differ from conventional follicular (FO) B cells both developmentally and functionally, are involved in early responses to infectious pathogens and the production of self-reactive antibodies. A novel gene, mzb1, is expressed at high levels in MZ and B1 B cells but at low level, if at all, in FO B cells. MZB1 is involved in the regulation of proliferation, BCR-mediated signal transduction, and antibody production in B cells. Inhibitors, activators and enhancers of MZB1 expression or activity can be used as immune modulators for research and therapeutic purposes.
