A two-piece catheter securement system has a separable, stand-alone fixation pad with an adhesive undersurface and an antimicrobial flap. On an upper surface of the pad are cooperative first attachment members. A separable, stand-alone upper capture and retention shell has an outer shell wall. The first and second ends of the shell may have a plurality of slots for capturing and retaining administration and catheter tubing. The shell has an inner shell ceiling having a plurality of spaced apart second attachment members thereon. The first and second attachment members are aligned to cooperatively engage when the shell is urged into releasable engagement with the pad with the slots capturing and retaining the tubes. The shell is fully separable from the pad when the cooperating attachment members are disengaged. The shell may be reused and the pad disposed.
