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Method for preparing electrospun fibers with a high content of a bioadhesive substance
专利权人:
AFYX Therapeutics A/S
发明人:
Hansen, Jens
申请号:
AU2018209592
公开号:
AU2018209592A1
申请日:
2018.01.22
申请国别(地区):
AU
年份:
2019
代理人:
摘要:
The present invention relates to a method for preparing electrospun fibers, the method comprising v) dissolving a fiber-forming hydrophilic polymer in an alcohol selected from C1-C3 alcohols, vi) dissolving a bioadhesive substance in water, wherein the bioadhesive substance has a solubility in water of 3 g/100 ml or more at 25 °C or g/100 ml or more at 25 °C, and wherein the bioadhesive substance has a solubility in an alcohol selected from C1-C3 alcohols of 0.5 g/100 ml 10 or less at 25 °C or 0.1g/100 ml or less at 25 °C, vii) adding under stirring the resulting solution from ii) to the resulting solu- tion from i), whereby the bioadhesive substance precipitates and a ho- mogeneous suspension is formed, wherein the bioadhesive substance is suspended as particles, and viii) electrospinning the homogeneous suspension to obtain hydrophilic fi- bers.
来源网站:
中国工程科技知识中心
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