The present disclosure relates to composition comprising Trigofoenoside, Vitexin, Iso-vitexin, Vitexin-2-o-rhamnoside Vicenin-1 and fiber, optionally along with pharmaceutically acceptable excipient(s) and method(s) of preparing said composition. The present disclosure also relates to methods of treating various conditions such as, but not limited to, Hypoxia, ulmonary Hypertension, Pulmonary Fibrosis and Sinusitis using the said composition.