System and method for irradiating a region of interest of a medical device, implanted in a biological tissue, and the surrounding tissue. The system includes a translucent wall having an optically diffusing component and, optionally, an associated source of light embedded therein. The optical diffuser is optionally configured to outcouple light with a uniform spatial distribution and may include a network of biocompatible waveguides. The system may include a catheter with a distal end with an embedded diffuser that outcouples light delivered from the external source through a spiral of optical fiber, buried in the wall of the catheter. The system may include a biocompatible layer permanently embedded into the biological tissue and containing quantum dots that are activated wirelessly, through the layer, to irradiate the surrounding tissue from inside. Such a layer does not need to be removed from the tissue after irradiation of the tissue has been accomplished.
