Compounds comprising are disclosed, wherein Y, A, X, R, D, and n are as described. A compound comprising a prostaglandin EP2 selective agonist wherein the omega-chain comprises a substituted phenyl, wherein at least one substituent consists of hydrocarbyl or non-linear hydroxyhydrocarbyl is also disclosed herein. Methods, compositions, and medicaments related thereto are also disclosed.本文揭示包含之化合物,其中Y、A、X、R、D及n係如本文所述。本文亦揭示包含前列腺素EP2選擇性激動劑之化合物,其中ω鏈包含經取代之苯基,其中至少一個取代基係由烴基或非直鏈羥基烴基組成。本文亦揭示與其相關之方法、組合物及藥物。