Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.本發明揭示用於治療及/或預防HIV感染及其症狀之基於酵母菌之免疫治療組合物、人類免疫缺乏病毒(HIV)抗原及融合蛋白質,以及利用該等基於酵母菌之免疫治療組合物、HIV抗原及融合蛋白質預防性及/或治療性處置HIV及/或其症狀之方法。