Man Lung YEUNG,Jasper Fuk-Woo CHAN,Johnson Yiu-Lam LAU,Kwok-Yung YUEN
申请号：
US15579528
公开号：
US20180149659A1
申请日:
2016.06.03
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods for treating, diagnosing, and providing prognostic information for kidney disease related to MERS-CoV infection are described. Transcription and translation products (for example, mRNA or peptides) of FGF2, Smad7, and/or sequences upstream of FGF2 are useful as markers that indicate kidney disease and/or provide prognostic information related to the course of kidney disease related to MERS-CoV infection. Such kidney disease can be treated and/or mitigated by reducing the availability of FGF2, Smad7, and/or a sequence upstream from FGF2 by reducing and/or regulating transcription and by sequestering related peptides using a large molecule binding partner, such as an antibody. Sequences for useful siRNAs and antisense oligonucleotides are provided.
