Fc-enhanced anti-WT1/HLA antibody

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专利权人:

Memorial Sloan-Kettering Cancer Center;Novartis AG;Eureka Therapeutics, Inc.

发明人:

Scheinberg, David,Veomett, Nicholas,Liu, Hong,Xiang, Jingyi,Liu, Cheng,Dao, Tao,Huet, Heather Adkins

申请号：

AU2014346648

公开号：

AU2014346648A1

申请日:

2014.11.07

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

The present disclosure relates to an anti-WT-1/HLA/A2 antibody with enhanced antibody dependent cell-mediated cytotoxicity (ADCC) function due to altered Fc glycosylation. The antibody, which has reduced fucose and/or galactose, was compared to its normally glycosylated counterpart in binding assays,

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