Hanson, Douglas Charles,Neveu, Mark Joseph,Mueller, Eileen Elliot,Hanke, Jeffrey Herbert,Gilman, Steven Christopher,Davis, C. Geoffrey,Corvalan, José Ramon
申请号：
EP20090007161
公开号：
EP2112166(B1)
申请日:
1999.12.23
申请国别(地区):
欧洲专利局
年份:
2018
代理人:
摘要：
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.
