#$%^&*AU2011202927A120120216.pdf#####ARTICULATING CLIP APPLIER CARTRIDGE Abstract An end effector (500) is provided and includes a distal housing portion (561b) and a proximal housing portion (561 a) interconnected to one another by a knuckle portion (510), wherein the knuckle portion permits rotation of the distal housing portion relative thereto and articulation of the distal housing portion relative to the proximal housing portion a jaw assembly (626) supported in the distal end of the distal housing portion, the jaw assembly including a first jaw (626a) and a second jaw (626b) movable between a spaced apart and an approximated position and a plurality of fasteners (580) loaded within the distal housing portion, each of the plurality of fasteners (580) defining a fastener axis extending in a direction substantially parallel to a pair of legs (582a, b) thereof, each of the plurality of fasteners being arranged within the base portion (581) such that the fastener axis is disposed at an angle with respect to a longitudinal axis of the distal housing portion.27/31 660 Ilk FIG. 41 43 FIG. 42 c1l FIG. 43