GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
发明人:
ANN LOUISE WALKER,CHRISTOPHER ROLAND WELLAWAY,CLEMENT DOUAULT,DAVID MATTHEW WILSON,DOMINIQUE AMANS,HAWA DIALLO,JESSICA FANNY RENAUX,JOHN LIDDLE,MATTHEW CAMPBELL,MICHAEL DAVID BARKER,NEIL STUART GARTON
申请号：
BR112017024678
公开号：
BR112017024678A2
申请日:
2016.05.19
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention relates to compounds of formula (I): wherein x, y, r1 and r3-r11 are as defined herein, and salts thereof are pad4 inhibitors and may be useful in treating various disorders. for example rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosus, and psoriasis.a presente invenção refere-se a compostos de fórmula (i): (i) em que x, y, r1 e r3-r11 são como aqui definidos, e sais dos mesmos são inibidores de pad4 e podem ser úteis no tratamento de vários distúrbios, por exemplo, artrite reumatoide, vasculite, lúpus eritematoso sistêmico, colite ulcerativa, câncer, fibrose cística, asma, lúpus eritematoso cutâneo, e psoríase.
