Provided is a novel trans-2-decenoic acid derivatives and pharmaceutical acceptable salts thereof, and a medicament comprising the compound as active ingredient and having a neurotrophic factor-like action with high safety and an alleviating action for side-effect caused by anti-cancer agent administration. The trans-2-decenoic acid derivatives or pharmaceutical acceptable salts thereof of the present invention are specifically represented by the general formula (1): (wherein, Y represents -O-, -NR- or -S-, R represents a hydrogen atom, alkyl or dialkylamino and the like, W represents a substituent, such as dialkylaminoalkyl and the like), and are extremely useful to be a medicament as a prophyalxic or treating agent for Dementia, Alzheimer's disease, Parkinson disease, depression and the like, as a treating or repairing agent for spinal cord injury, or as an alleviating agent for side-effect caused by anti-cancer agent administration and the like.
