Disclosed are a pharmaceutical composition particle capable of both masking unpleasant taste and improving dissolution, an orally disintegrating tablet containing the same, and a method for producing the pharmaceutical composition particle. The pharmaceutical composition particle comprises a core particle containing a water-soluble gelling swelling substance, an intermediate layer containing a drug and covering the outside of the core particle, and a water-insoluble substance covering the outside of the intermediate layer And an outer layer. Moreover, an orally disintegrating tablet contains the above-mentioned pharmaceutical composition particles.不快な味のマスキングと溶出性の改善の両立が可能な医薬組成物粒子とそれを含む口腔内崩壊錠と、医薬組成物粒子の製造方法を提供する。医薬組成物粒子は、水溶性のゲル化膨潤物質を含有する核粒子と、薬物を含有して核粒子の外側を被覆する中間層と、水不溶性物質を含有して中間層の外側を被覆する外層とを備える。また、口腔内崩壊錠は、上述の医薬組成物粒子を含む。
