The invention relates to the use of cannabinoid-containing plant extracts inthe prevention or treatment of neural degeneration. In particular, theinvention relates to use of one or more cannabinoid-containing plant extractsin the prevention or treatment of neural degeneration, wherein the one or morecannabinoid-containing plant extracts comprise: i) a cannabinoid-containingfraction; and ii) a non-cannabinoid containing fraction.