1-oxo-isoindoline-4-carboxamides and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamides derivatives, their preparation and their therapeutic application.
Andreas Karlsson,Arielle Genevois-Borella,Bernard Baudoin,Jean-Luc Malleron,MAGALI MATHIEU,Michel Evers
申请号：
BRPI0813624
公开号：
BRPI0813624A2
申请日:
2008.07.25
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
1-Oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide compounds (I) and their base or acid addition salts, hydrates or solvates are new. 1-Oxo-isoindoline-4-carboxamide and 1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide compounds of formula (I) and their base or acid addition salts, hydrates or solvates are new. R 1>；H, 1-10C alkyl, 3-7C cycloalkyl, (CH 2) n-(1-6C)alkenyl, (CH 2) n-(1-6C)alkynyl, 1-6C alkyl-Z-(1-6C alkyl), aryl or aralkyl (all optionally substituted by halo, 1-6C alkyl, 3-7C cycloalkyl, halo(1-6C)alkyl, 1-6C alkoxy, halo(1-6C)alkoxy, NR 7>；R 8>；, nitro, cyano, OR, COOR, CONR 7>；R 8>；or S(O) mNR 7>；R 8>；), COOR or S(O) mR； Z : heteroatom comprising O, N or S(O) m； R 2>；halo(1-6C)alkyl, halo(1-6C)alkoxy, OH, 1-6C alkoxy, NO 2, CN, NH 2, NR 7>；R 8>；, COOR, CONR 7>；R 8>；, OCO(1-6C)alkyl, S(O) mNR 7>；R 8>；or aryl (all optionally substituted by one or more halo, 1-6C alkyl, 3-7C cycloalkyl, halo(1-6C)alkyl, (1-6C)alkoxy, halo(1-6C)alkoxy, NR 7>；R 8>；, NO 2, CN, OR, COOR, CONR 7>；R 8>；or S(O) mNR 7>；R 8>；), H (preferred), halo, 1-6C alkyl, 3-7C cycloalkyl, (1-6C)alkenyl, (1-6C)alkynyl or 1-6C alkyl-Z-(1-6C alkyl)； R 3>；CF 3； either R 4>；, R 5>；H； or CR 4>；R 5>；ring containing 3-6 carbon atoms (optionally saturated and optionally containing 0 or 1 heteroatom comprising O, N or S)； R 6>；H (preferred), halo, 1-6C alkyl, 3-7C cycloalkyl, 3-7C cycloalkyl-1-6C alkyl, NO 2, NH 2, NR 7>；R 8>；, COOR, NR 7>；(SO 2)R 8>；, CONR 7>；R 8>；or aryl； either R 7>；, R 8>；, R : H, 1-6C alkyl, 3-7C cycloalkyl, 3-7C cycloalkyl-1-6C alkyl, aryl, aryl(1-6C)alkylene or COR； or R 7>；R 8>；ring containing 5-7 carbon atoms (optionally saturated and substituted by heteroatom of O, N or S(O) m)； X : 1-2C alkylene (optionally substituted by one or more 1-6C alkyl group)； m : 0-2； and n : 1-6. Where the carbon carrying the benzyl substituted by R2 is absolute configuration S and the
