The present invention includes novel substituted bicyclic compounds, and compositions comprising the same, that can be used to treat or prevent hepatitis B virus (HBV) infections in a patient. In certain embodiments, the compounds and compositions of the invention are capsid inhibitors.本發明包括新的被取代的雙環化合物,以及包含該化合物的組合物,其可用於治療或預防患者被B型肝炎病毒(HBV)感染。在某些實施例中,本發明的化合物及組合物係病毒外殼抑制劑。