The present invention relates to a PCV2 ORF2 protein for use in a method for the reduction of the viral load, for the reduction of the infection quota and/or the reduction of the infection pressure in a herd of swine caused by an infection with PCV2. In particular, the present invention relates to any method described above, wherein said PCV2 ORF2 protein is to be administered at regular intervals to female animals of a herd and to piglets.
