A method of removing thrombus accumulation from a space between a body valve and a wall of a body vessel is described herein. The method can include an occlusion catheter with a first occlusion member positioned on the second side of the vessel. An aspiration catheter is introduced through the vessel and the valve. The aspiration catheter can have a nozzle with a bent configuration to position the end opening proximate to the thrombus accumulation.
