Disclosed is an antimicrobial bio polyurethane foam and a method for manufacturing thereof, and more specifically, a polyurethane foam which comprises a reaction product of a resin premix comprising the biopolyol in an amount of 5 to 30 wt % based on total weight of the resin premix, and a prepolymer. The antimicrobial bio polyurethane foam is enhanced in an antimicrobial property by maximizing the content of the biopolyol.
