Aya JAKOBOVITS,Soudabeh ETESSAMI,Pia M. CHALLITA-EID,Juan J. PEREZ-VILLAR,Karen J. MORRISON,Xiao-Chi JIA,Mary FARIS,Jean GUDAS,Arthur B. RAITANO
申请号：
US15448430
公开号：
US20170275377A1
申请日:
2017.03.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response； antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization
