INHIBITEURS DE LTBP PROPRES À UN COMPLEXE DE TGF-BÉTA ET LEURS UTILISATIONS

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专利权人:

Scholar Rock; Inc.

发明人:

申请号：

EP20154732.0

公开号：

EP3689905A2

申请日:

2020.01.30

申请国别(地区):

EP

年份:

2020

代理人:

摘要：

Disclosed herein are inhibitors, such as antibodies, and antigen-binding portions thereof, that selectively bind complexes of LTBP1-TGFβ and/or LTBP3-TGFβ. The application also provides methods of use of these inhibitors for, for example, inhibiting TGFβ activation, and treating subjects suffering from TGFβ-related disorders, such as fibrotic conditions. Methods of selecting a context-dependent or context-independent isoform-specific TGFβ inhibitor for a subject in need thereof are also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/