Allison Coffin,Phillip Michael Uribe,Jie Xu,Zecong Fang
申请号：
US16375271
公开号：
US20190311703A1
申请日:
2019.04.04
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Hair cells are exquisitely sensitive to auditory stimuli, but also to damage from a variety of sources including noise trauma and ototoxic drugs. Mammals cannot regenerate cochlear hair cells, while non-mammalian vertebrates exhibit robust regenerative capacity. To allow for the effective examination of this process disclosed herein is a design and method of utilizing a device capable of inducing acoustic trauma in the larval lateral line. The device uses ultrasonic transducers to induce cavitation wherein microbubbles form in the fluid medium inside the container. These bubbles oscillate and then implode, sending shockwaves into the fluid inside the well-plate containing the fish. The device emits a broadband signal with peak sound energy in the low-frequency range below 200 Hz, consistent with the response range of the larval lateral line.
