PROCEDES ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES PROLIFERATIVES

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专利权人:

PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人:

申请号：

EP08742421.4

公开号：

EP2142566B1

申请日:

2008.03.31

申请国别(地区):

EP

年份:

2016

代理人:

摘要：

The invention features peptides containing domain 4 of the Streptococcus intermedius intermedilysin (ILY) protein and fragments thereof, and the use of these peptides to sensitize cancer cells to antibody based anticancer treatments. CD59 receptor activity has been associated with a decreased sensitivity to therapeutic antibodies. Desirably, administration of ILY domain 4 polypeptides is sufficient to inhibit CD59 receptor activity while avoiding the general toxicity associated with full length ILY.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/