The invention provides methods for treating cancer/tumor growth by administering a Dll4 antagonist, in particular, Dll4 antibodies and fragments thereof that specifically bind human Dll4, optionally with a VEGF antagonist and chemotherapeutic agents. Pharmaceutical compositions and kits containing Dll4 antagonists, VEGF antagonists and chemotherapeutic agents are also provided.本發明提供治療癌症/腫瘤生長的方法,其是藉由投與Dll4拮抗劑,具體而言是特異地結合人類Dll4的Dll4抗體與其片段,視情況與VEGF拮抗劑以及化療劑一起。亦提供含有Dll4拮抗劑、VEGF拮抗劑以及化療劑的醫藥組成物與套組。