CORNFELD, MARK J.,KUMAR, RAKESH,MORRIS, SHANNON RENAE
申请号：
CA2923899
公开号：
CA2923899A1
申请日:
2014.10.01
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
A novel combination comprising an androgen receptor inhibitor, for example: 4- (3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2- fluoro-N-methylbenzamide or a pharmaceutically acceptable salt thereof, and an AKT inhibiting compound, for example: N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5- chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents； pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which androgen receptor inhibition and/or AKT inhibition is beneficial, e.g., cancer.
