Bradley Teegarden,Hongmei Li,Honnappa Jayakumar,Peter Ian Dosa,Sonja Strah-Pleynet
申请号：
BRPI0412263
公开号：
BRPI0412263B1
申请日:
2004.07.21
申请国别(地区):
BR
年份:
2019
代理人:
摘要：
"Diaryl and aryletheroaryl urea derivatives as 5-ht2a serotonin receptor modulators useful for the prophylaxis and treatment of related disorders." The present invention relates to certain pyrazole derivatives of formula (I) and their pharmaceutical compositions which modulate 5-ht-2a- serotonin receptor activity. The compounds and their pharmaceutical compositions refer to methods useful in the prophylaxis or treatment of platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, arterial fibrillation, reducing the risk of blood clot formation. blood, asthma or its symptoms, restlessness or a symptom, behavioral disorders, drug-induced psychosis, excitatory psychosis, gilles de la tourette syndrome, manic disorder, organic or nos psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, us schizophrenia and related disorders, and sleep disorders, diabetic related disorders and the like. The present invention also relates to the method of prophylaxis or treatment of 5-ht-2a serotonin receptor-mediated disorders in combination with a dopamine d2 receptor antagonist such as haloperidol, administered separately or together."derivados de diaril e arileteroaril uréia como moduladores do receptor de serotonina de 5-ht2a úteis para a profilaxia e tratamento de desordens relacionadas aos mesmos". a presente invenção refere-se a certos derivados de pirazóis da fórmula (i) e suas composições farmacêuticas que modulam a atividade do receptor de serotonina de 5-ht~ 2a~. compostos e suas composições farmacêuticas referem-se a métodos úteis na profilaxia ou tratamento de agregação de plaquetas, doença de artéria coronária, infarto do miocardio, ataque isquêmico transitório, angina, acidente vascular cerebral, fibrilação arterial, reducing the risk de formação de coágulo de sangue, asma ou seus sintomas, agitação ou um sintoma, desordens comportamentais, psicose induzida pela droga, psicose excitativ
