Synthetic peptide for repressing transcription and/or gene expression from a binding site of interest

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专利权人:

发明人:

Christopher T. Nomura,Benjamin R. Lundgren

申请号：

US15175589

公开号：

US09879051B2

申请日:

2016.06.07

申请国别(地区):

US

年份:

2018

代理人:

摘要：

A synthetic peptide includes an amino acid sequence that: has 70-75%, 75-80%, 80-85%, 85-90%, 90-95% or 95-100% homology with an RpoN box of Region III of an RpoN protein and binds specifically to a −24, −12, or −24/−12 site(s) of an RpoN promoter. The synthetic peptide is effective for repressing transcription and/or gene expression from a binding site of interest, and the binding site of interest is an RpoN binding site or a cryptic promoter upstream of an RpoN binding site.

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