[Problem]To provide a tablet guiding path adjusting apparatus for a tablet cassette which automatically adjusts a dimension of a tablet guiding path promptly in accordance with the shape or size of a tablet received into the tablet cassette.[Solution]Provided is a tablet guiding path adjusting apparatus that adjusts a tablet guiding path adjusting mechanism in the tablet cassette, comprising a rotor 8 rotatably equipped within a cassette body 5 and having a tablet guiding path 8a for receiving at least one of tablets received within the cassette body and guiding to a discharging orifice 9 of the cassette body; a partition member 20 for entering the tablet guiding path and being located between a tablet at the lowest part and a tablet at the upper side thereof; and tablet guiding paths adjusting mechanisms M2, M3, and M4 configured to adjust at least either dimension of the depth and width of the tablet guiding path 8a to the rotor; wherein the tablet guiding path adjusting apparatus engages with engaging parts 33c, 52b, and 95d of the tablet guiding path adjusting mechanisms to operate the tablet guiding path adjusting mechanism, and adjusts a dimension of the tablet guiding path in accordance with the shape or size of tablets received within the cassette body.