Eric M. Bennett,Nathan Higginson-Scott,Lioudmila Tchistiakova,Kimberly A. Marquette,Janet E. Paulsen,Ruth E. Gimeno
申请号：
US15309879
公开号：
US10392438B2
申请日:
2015.05.13
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. The present invention also relates to a humanized antibody that specifically binds human TrkB and methods for producing and using the antibody to, inter alia, treat a hearing loss disorder.
