A fiber optic medical device/system is presented, comprising laser source, connectible to optical fibers and enclosed to ensure sterility and safe operation. It is a single use system enclosed and sterilized, including laser source and, optical fiber attached in a sterile tube. Another embodiment is hermetically sealed laser unit with simple connection system to a properly shaped fiber optic. Joined hand piece and fiber can be directly inserted to treat target tissue. Laser handle is aseptically packaged. In other embodiments, fiber is proximally terminated in solid funnel-shaped end to provide unique directional keyed junction with laser unit. In another embodiment, unit includes fiber joined to it, where a laser module can be added away from the fiber end and laser module need not be sterilized, but entire unit is safe for medical use in sterile fields. Enclosure also serves as handpiece for manipulating device. Another preferred embodiment has laser unit attached to a rigid delivery system for laparoscopic procedures.