MIXED MICELLES INCLUDING AMPHIPATHIC CONJUGATES OF RNA AGENTS, AND USES THEREOF

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专利权人:

NORTHEASTERN UNIVERSITY

发明人:

TORCHILIN, VLADIMIR,LEVCHENKO, TATYANA, S.

申请号：

EP08826166

公开号：

EP2171095A4

申请日:

2008.07.07

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

Disclosed are improved pharmaceutical formulations for the delivery of RNA interference agents, such as antisense RNA, micro-RNA and siRNA. The formulations employ mixed micelles including amphipathic conjugates of the iRNA agents and amphipathic micelle-forming molecules with extended hydrophilic chains. Also disclosed are methods of using the pharmaceutical formulations to increase delivery of an iRNA agent to an intracellular target, and to decrease extracellular nuclease degradation of an iRNA agent in the formulations.

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中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/