Systems, devices, and methods are provided to provide medical imaging and measurement of features with a lumen of a patient. An intraluminal imaging system may be configured to receive imaging data from an imaging device positioned within the lumen and identify and measure features within the imaging data, such as lesions and stents. The measurements may be used to generate a lesion score and/or an expansion score. The lumen score, expansion score, and associated measurements may be displayed to a user to assist in further imaging procedures or treatment options for the patient.