An intra-oral phototherapy device comprising: a handle; at least one mouthpiece removably connectable to the handle; and at least one light source in the mouthpiece adapted to direct light inside a mouth of a user (Figure 2). In addition, an extra-oral phototherapy device is provided with a headband with two earcups; wherein each earcup has an earcup projection comprising at least one light source adapted to direct light at least partially over a temporomandibular joint of a wearer (Figure 4).