David J. Chaplin,Charles Manly Garner, III,Robert Ronald Kane,Kevin G. Pinney,Joseph Anthony Prezioso,Klaus Edvardsen
申请号：
US14180238
公开号：
USRE045907E1
申请日:
2014.02.13
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubulin-binding stilbenoid analogs structurally related to combretastatin A-1 and combretastatin A-4. The prodrug forms serve as potent vascular targeting agents (VTAs) useful for the treatment of solid tumor cancers and diseases associated with retinal neovascularization.
